Unlike other hantaviruses, SEOV has a global distribution due to the worldwide dispersal of its carrier host ( Rattus sp). The most common and widespread hantavirus across northern, central and eastern Europe is PUUV, which is associated with the mildest form of HFRS.
The relative geographic distribution of each hantavirus is defined by their reservoir host.
Serial cloner 2.6.1 plus#
Surveillance in Europe has detected six rodent-borne hantaviruses Dobrava-Belgrade virus (DOBV), Saaremaa virus (SAAV), Seoul virus (SEOV), Puumala virus (PUUV), Tatenale virus (TATV) and Tula virus (TULV) plus two insectivore-borne hantaviruses Seewis virus (SWSV) and Nova virus (NVAV). Whilst infected reservoir hosts are asymptomatic, human infections can lead to two clinical manifestations, haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), with varying degrees of morbidity and mortality. Transmission to humans is primarily via inhalation of aerosolised virus in contaminated rodent urine and faeces. Each hantavirus appears to be adapted and largely restricted to an individual reservoir host species, implying that they have co-evolved, although phylogenetic analyses suggests that this apparent co-evolution may be more attributed to recent preferential host switching and local adaptation. Unlike other members of the Bunyaviridae, hantaviruses are not transmitted by arthropods but primarily by rodents of the families Cricetidae and Muridae, although insectivore and bat hosts have also been reported. Hantaviruses (family Bunyaviridae, genus Hantavirus) are single-stranded RNA viruses. Under-reporting and difficulties in identifying the hantaviruses associated with HFRS may mask the public health impact of SEOV in Europe. The detection of SEOV in two wild caught brown rats in the UK and the multiple detection of SEOV infected brown rats in the Lyon region of France, suggests that SEOV is circulating in European brown rats. We obtained significantly improved recovery of virus genome sequence directly from SEOV infected lung material using a simple viral enrichment approach and NGS technology. Sequence data obtained from the recent human SEOV case (Replonges) was most similar to that obtained from one brown rat trapped in a public park in Lyon city centre. Phylogenetic analysis supports the inclusion of the Lyon SEOV within Lineage 7 with SEOV strains originating from SE Asia and the previously reported French & Belgian SEOV strains. SEOV RNA was detected in the lungs of 14% (95% CI 8.01 – 20.11) of brown rats tested using a nested pan-hantavirus RT-PCR (polymerase gene). Methodsīetween October 2010 and March 2012, 128 brown rats were caught at sites across the Lyon region in France. The incidence of rodent and human cases of Seoul virus (SEOV) in Europe has been considered to be low, and speculated to be driven by the sporadic introduction of infected brown rats ( Rattus norvegicus) via ports. Whilst infected reservoir hosts are asymptomatic, human infections can lead to two clinical manifestations, haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), with varying degrees of clinical severity. Hantaviruses are single-stranded RNA viruses, which are transmitted to humans primarily via inhalation of aerosolised virus in contaminated rodent urine and faeces.
0 kommentar(er)
